Focusing on structural and functional studies of membrane transport proteins, the Alam lab is fully outfitted for mammalian cell culture and optimization and large-scale protein expression and purification as well as biochemical analysis. Projects will enjoy fantastic access to a state-of-the-art in-house Cryo-EM facility featuring a Titan Krios microscope equipped with a Gatan KIII-Biocontinuum Direct electron detector/energy filter combination. The Hormel Institute also houses an equipment core including fluorescent microscopes as well as analytical ultracentrifugation, ITC and BIACORE instruments, along with shared common use high speed centrifuges and a range of other high-end microscopes. The core facilities are further supported by dedicated facility managers responsible for train